Ohio State University - United States
Author Profile
Scopus
🎓 Early Academic Pursuits
Dr. Tianmin Fu's academic journey began with a passion for biological sciences, earning his B.S. in Biological Sciences from Shandong University in 2005, where he was recognized with multiple scholarships, including the prestigious University-Admission Scholarship. He pursued his Ph.D. in Biochemistry and Molecular Biology at Peking University, graduating magna cum laude in 2011. During his doctoral studies, he received the Tsai-Fan Yu and Gu Wenyu Fellowships, solidifying his foundation in structural biology and molecular mechanisms.
💼 Professional Endeavors
Dr. Fu's professional trajectory is marked by distinguished roles at leading research institutions. He started as a Postdoctoral Associate at Weill Cornell Medical College, followed by Research Fellow and Instructor positions at Harvard Medical School and Boston Children’s Hospital. Since 2020, he has been an Assistant Professor in the Department of Biological Chemistry and Pharmacology at The Ohio State University, contributing to groundbreaking research in structural biology and cancer biology. His research emphasizes molecular mechanisms underlying cellular and immunological processes.
🔬 Contributions and Research Focus
Dr. Fu’s research is focused on elucidating the structural and molecular mechanisms of critical biological pathways, with a particular emphasis on V-ATPases, inflammasomes, and cancer immunotherapy. His groundbreaking work has been supported by several major grants, including the NIGMS R35 GM147465-01 grant for studying V-ATPases and their role in assembly, biogenesis, regulation, and function. His contributions to understanding inflammasome modulation and mechanosensitive channels demonstrate his commitment to advancing structural biology for therapeutic development.
🌍 Impact and Influence
Dr. Fu’s impact extends across disciplines, evidenced by his significant contributions to structural biology and cancer immunotherapy. His research has not only advanced the understanding of molecular mechanisms but has also provided insights into novel therapeutic targets. Recognition from peers includes awards such as the Kenneth Fong Young Investigator Award, Research Excellence Award at Harvard Medical School, and multiple prestigious fellowships.
🏆Academic Cites
Dr. Fu's innovative research is well-documented in high-impact publications, earning significant citations that highlight the relevance and influence of his work. His investigations into inflammasomes, V-ATPases, and other molecular systems are frequently referenced, cementing his position as a thought leader in the field of structural biology.
🌟 Legacy and Future Contributions
Dr. Fu's legacy is defined by his pioneering research and dedication to mentorship. His current work on cancer immunotherapy and structural mechanisms promises to open new avenues for therapeutic interventions. By bridging the gap between molecular insights and clinical applications, Dr. Fu is poised to make transformative contributions to biomedical science and structural biology.
📝Structural Biology
Dr. Tianmin Fu's extensive research in structural biology focuses on molecular mechanisms of V-ATPases, inflammasomes, and mechanosensitive channels, which has advanced understanding in biochemistry and pharmacology. His commitment to structural biology is evident in his high-impact grants and publications. Through his innovative approach, Dr. Fu continues to shape the future of structural biology with applications in cancer immunotherapy and cellular biology.
Notable Publication
📝DdmDE Eliminates Plasmid Invasion by DNA-Guided DNA Targeting
Authors: Yang, X.-Y., Shen, Z., Wang, C., Nakanishi, K., Fu, T.-M.
Journal: Cell
Year: 2024
Citations: 2
📝Molecular Basis of Gabija Anti-Phage Supramolecular Assemblies
Authors: Yang, X.-Y., Shen, Z., Xie, J., Wysocki, V.H., Fu, T.-M.
Journal: Nature Structural and Molecular Biology
Year: 2024
Citations: 3
📝PtuA and PtuB Assemble Into an Inflammasome-Like Oligomer for Anti-Phage Defense
Authors: Li, Y., Shen, Z., Zhang, M., Fu, T.-M., Yu, Y.
Journal: Nature Structural and Molecular Biology
Year: 2024
Citations: 6
📝Human V-ATPases: Assembly, Function, and Regulation
Authors: Fosuah, E., Lin, Q., Fu, T.-M.
Book Title: Cryo-Electron Microscopy in Structural Biology: From Structural Insights to Tomography and Drug Discovery
Year: 2024
Citations: 0
📝Structures and Functions of Short Argonautes
Authors: Wang, C., Shen, Z., Yang, X.-Y., Fu, T.-M.
Journal: RNA Biology
Year: 2024
Citations: 0