Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences) - China
Author Profile
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🎓 Early Academic Pursuits
Ms. Xia Tong’s academic journey in chemistry began at Shanxi Normal University, where she completed her Bachelor’s degree in 2014. She continued her studies at Central South University, earning her Master’s in Chemical Sciences in 2017 under the supervision of Associate Professor Zhang Zhimin. Driven by a passion for advancing diagnostic technologies, she pursued her PhD in Chemical Sciences, also at Central South University, where she conducted cutting-edge research on biosensing technologies. Her doctoral work, under the guidance of Professor Shi Shuyun, focused on carbon dot fluorescence sensors for enzyme activity detection, laying a strong foundation for her subsequent research in medical diagnostics.
💼 Professional Endeavors
Since December 2022, Ms. Xia Tong has been an Associate Researcher at the Stem Cell Translation Laboratory of Shanxi Bethune Hospital. In this role, she has initiated several prominent research projects, including leading the Shanxi Bethune Hospital Talent Introduction Scientific Research Start-up Fund (2023RC02). This project focuses on a biosensing-based system utilizing peroxidase-uricase for the localized sensing and treatment of acute gouty arthritis, underscoring her commitment to developing practical solutions for real-time diagnostic applications. Another notable project she leads is the Shanxi Province Basic Research Program, which centers on real-time detection of rheumatoid arthritis markers via fluorescent microfluidic paper chips.
🔬 Contributions and Research Focus
Ms. Xia’s research primarily revolves around developing innovative biosensing platforms for disease diagnosis and treatment. During her doctoral studies, she pioneered the use of carbon dot fluorescence sensors for the simultaneous detection of γ-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) activity in human serum, a breakthrough in enzyme activity detection. Her work has extended to food safety as well, with the development of 3D microfluidic paper-based devices (T-3D μPADs) for the interference-free detection of organophosphorus pesticide residues in agricultural products. Additionally, she designed a smartphone-integrated portable paper-based syringe device, enabling visual and rapid detection of 2,4-Dichlorophenoxyacetic acid, a common herbicide, underscoring her contributions to public health and safety.
🌍 Impact and Influence
Ms. Xia Tong’s innovative research in biosensing has led to advancements in diagnostic and treatment technologies. Her integration of μPAD-based technology for detecting rheumatoid arthritis markers such as rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (ACPA), and C-reactive protein (CRP) has set a new standard for analytical devices in disease diagnostics. This work not only aids in the early detection of rheumatoid arthritis but also aligns with the goals of personalized and precision medicine. Her recent project on integrating microfluidic chips with hollow microneedles for gouty arthritis treatment highlights her influence in advancing minimally invasive and patient-friendly therapeutic methods.
🏆Academic Cites
Ms. Xia’s contributions to the field of biosensing and medical diagnostics have garnered attention in academic circles, with her research frequently cited in studies focused on enzyme detection and biosensor applications. Her work on carbon dot fluorescence sensors and microfluidic devices has become a valuable resource for researchers aiming to develop high-throughput, sensitive diagnostic platforms. These citations underscore the widespread relevance of her research and the scientific community’s recognition of her contributions.
🌟 Legacy and Future Contributions
Ms. Xia Tong’s legacy will be defined by her groundbreaking work in biosensing technologies and her dedication to advancing diagnostic tools that benefit public health. Her future contributions are poised to further refine and expand applications of biosensor technology, particularly in the areas of arthritis treatment and real-time diagnostic markers. By advancing the design of microfluidic platforms and enhancing their integration with treatment methodologies, Ms. Xia is set to continue her influential role in clinical diagnostics and health technology innovation, ensuring her lasting impact on the field.
📝Notable Publication
📝Adhered-3D Paper Microfluidic Analytical Device Based on Oxidase-Mimicking Activity of Co-Doped Carbon Dots Nanozyme for Point-of-Care Testing of Alkaline Phosphatase
Authors: Guo, J., Zhang, J., Tong, X.
Journal: Analytica Chimica Acta
Year: 2024
Citations: 0
📝📝Multi-Emitting Fluorescent System–Assisted Lab-in-a-Syringe Device for On-Site and Background-Free Detection of 2,4-Dichlorophenoxyacetic Acid
Authors: Tong, X., Wang, T., Cao, Y., Jiang, Q., Guo, Y.
Journal: Food Frontiers
Year: 2023
Citations: 6
📝A Dual-Emission Carbon Dots-Based Nonenzymatic Fluorescent Sensing Platform for Simultaneous Detection of Parathion-Methyl and Glyphosate
Authors: Yang, Y., Tong, X., Chen, Y., Shi, S., Guo, Y.
Journal: Food Chemistry
Year: 2023
Volume: 403
Citations: 34
📝Threaded 3D Microfluidic Paper Analytical Device-Based Ratiometric Fluorescent Sensor for Background-Free and Visual Detection of Organophosphorus Pesticides
Authors: Tong, X., Cai, G., Xie, L., Shi, S., Guo, Y.
Journal: Biosensors and Bioelectronics
Year: 2023
Citations: 37
📝Solvent-Mediated In Situ Growth and Assembly of Gold Nanoparticles@Carbon Dots for Rapid Colorimetric Nonenzymatic Alcohol Sensing
Authors: Tong, C., Tong, X., Cao, Y., Shi, S., Guo, Y.
Journal: Carbon
Year: 2022
Citations: 11
📝Highly Specific Esterase Activated AIE Plus ESIPT Probe for Sensitive Ratiometric Detection of Carbaryl
Authors: Fan, L., Tong, C., Cao, Y., Shi, S., Guo, Y.
Journal: Talanta
Year: 2022
Citations: 12